Optomotor response (OMR) is a reflex used to assess vision in mice. In order to evoke OMR, a mouse watches a rotating cylinder with a striped pattern. Stimulus correlated head movements are quantified to determine visual thresholds. The qOMR (quantitative OMR) is a unique system that automatically measures OMR with minimal experimenter effort. It uses a virtual stimulation sphere that constantly aligns with the animal´s head position. Based on real-time head tracking quantitative OMR measurements run fully automatically and objectively.